Computer-Aided TB Screening for HIV+ Population Using Chest X-Rays

Banner image collage showing 4 pictures: portable x-ray device, mobile x-ray truck, chest-xray, and map of Kenya

Tuberculosis (TB) is one of the world’s deadliest communicable diseases is widespread, particularly in resource challenged parts of the world. TB is a severe comorbidity in immunocompromised HIV+ and is correlated with poor control in developing nations. Rapid TB detection tests are needed in endemic resource-constrained regions for appropriate treatment protocols.

Since the lack of sufficient radiological services in the area suggests the utility of automation to perform the screening, our in-house research effort applying our expertise in image analysis and machine learning focuses on developing software to automatically screen for disease in digital Chest X-ray (CXR) images. Radiological analysis of CXR images is a routine component in diagnosing pulmonary TB.

Publications/Tools

Xue Z, Long LR, Jaeger S, Folio L, Thoma GR. Extraction of Aortic Knuckle Contour in Chest Radiographs Using Deep Learning. EMBC 2018.
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Rajaraman S, Candemir S, Xue Z, Alderson P, Kohli M, Abuya J, Thoma GR, Antani SK. A novel stacked generalization of models for improved TB detection in chest radiographs. Proc. IEEE Engineering in Medicine and Biology Conference (EMBC 2018), Honolulu, Hawaii, 2018. pp. 718-721.
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Rajaraman S, Antani SK, Candemir S, Xue Z, Abuya J, Kohli M, Alderson P, Thoma GR. Comparing deep learning models for population screening using chest radiography. Proc. SPIE 10575, Medical Imaging 2018: Computer-Aided Diagnosis, 105751E (27 February 2018).
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Xue Z, Jaeger S, Antani SK, Long LR, Karargyris A, Siegelman J, Folio LR, Thoma GR. Localizing tuberculosis in chest radiographs with deep learning. SPIE Medical Imaging 2018
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Xue Z, Antani SK, Long LR, Thoma GR. Using deep learning for detecting gender in adult chest radiographs. SPIE Medical Imaging 2018
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Rajaraman S, Antani SK, Xue Z, Candemir S, Jaeger S, Thoma GR. Visualizing abnormalities in chest radiographs through salient network activations in Deep Learning. Proc. IEEE Life Sciences Conference (LSC), Sydney, Australia, 2017. pp. 71-74, DOI:10.1109/LSC.2017.8268146.
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Guan Y, Li M, Jaeger S, Lure F, Raptopoulos V, Lu P, Folio LR, Candemir S, Antani SK, Siegelman J, Li J, Wu T, Thoma GR, Qu S. Applying Artificial Intelligence and Radiomics for Computer Aided Diagnosis and Risk Assessment in Chest Radiographs. 2nd Conference on Machine Intelligence in Medical Imaging (CMIMI) of the Society for Imaging Informatics in Medicine (SIIM), Poster, 2017.
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Moallem G, Jaeger S, Poostchi M, Palaniappan N, Yu H, Silamut K, Maude RJ, Antani SK, Thoma GR. White Blood Cell Detection and Segmentation in Microscopy Images of Thin Blood Smears [Poster]. NIH Research Festival, Poster, 2017
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Moallem G, Poostchi M, Yu H, Palaniappan N, Silamut K, Maude RJ, Hossain Md Amir, Jaeger S, Antani SK, Thoma GR. Detecting and Segmenting White Blood Cells in Microscopy Images of Thin Blood Smears [Poster]. Annual Meeting of the American Society of Tropical Medicine & Hygiene (ASTMH), Poster, 2017
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Lure F, Jaeger S, Antani SK. Automated Systems for microscopic and radiographic tuberculosis screening. Electronic Journal of Emerging Infectious Diseases, Vol. 2, No. 1, pp. 5-9, February 2017. [In Chinese]
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Candemir S, Jaeger S, Lin W, Xue Z, Antani SK, Thoma GR. Automatic heart localization and radiographic index computation in chest x-rays. Proc. SPIE. 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 978517. DOI: 10.1117/12.2217209.
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Candemir S, Jaeger S, Antani S, Bagci U, Folio LR, Xu Z, Thoma G. Atlas-based rib-bone detection in chest X-rays. Comput Med Imaging Graph. 2016 Jul;51:32-9. doi: 10.1016/j.compmedimag.2016.04.002. Epub 2016 Apr 13.
Abstract | URL: https://www.sciencedirect.com/science/article/pii/S0895611116300337 | PMID: 27156048 | PMCID: PMC4923658

Jaeger S, Candemir S, Antani SK, Wang Y, Lu P, Thoma GR. Two public chest X-ray datasets for computer-aided screening of pulmonary diseases. Quant Imaging Med Surg. 2014 Dec;4(6):475-7. doi: 10.3978/j.issn.2223-4292.2014.11.20.
Abstract | PDF | PMID: 25525580 | PMCID: PMC4256233

Antani SK. Automatic x-ray screening for tuberculosis. SPIE Newsroom. October 2015. DOI: 10.1117/2.1201509.006128
Abstract | PDF | URL: http://spie.org/x115742.xml?highlight=x2416

Xue Z, Candemir S, Antani SK, Long LR, Jaeger S, Demner-Fushman D, Thoma GR. Foreign Object Detection in Chest X-rays. Proc IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2015, International Workshop on Biomedical and Health Informatics, Bethesda, Maryland, Nov. 9-12, 2015, pp: 56-61.
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Folio, L, Sigelman, J, Wang, Y, Lu, P, Antani SK, Jaeger S. Automatic Identification and Classification of Tuberculosis Findings on Chest Radiographs for Global Surveillance Programs [Abstract]. Annual Meeting of the American Roentgen Ray Society (ARRS)
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KC S, Antani SK, Thoma GR. Stitched Multipanel Biomedical Figure Separation. IEEE, 28th International Symposium on Computer-Based Medical Systems (CBMS), pp. 54-59, 2015.
Abstract | PDF | URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7167457

KC S, Vajda S, Antani SK, Thoma GR. Automatic Pulmonary Abnormality Screening using Thoracic Edge Map. IEEE, 28th International Symposium on Computer-Based Medical Systems (CBMS), pp. 360-361, 2015.
Abstract | URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7167519

KC S, Xue Z, Antani SK, Thoma GR. NLM at ImageCLEF 2015: Biomedical Multipanel Figure Separation. Editors: Cappellato, L., Ferro, N., Jones, G., and San Juan, E., CLEF 2015 Labs and Workshops, Notebook Papers. CEUR WorkshopProceedings (CEUR-WS.org), ISSN 1613-0073, http://ceur-ws.org/ Vol-1391/.
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Karargyris A, Siegelman J, Tzortzis D, Jaeger S, Candemir S, Xue Z, KC S, Vajda S, Antani SK, Folio L, Thoma GR. Combination of texture and shape features to detect pulmonary abnormalities in digital chest X-rays. Int J Comput Assist Radiol Surg. 2016 Jan;11(1):99-106. doi: 10.1007/s11548-015-1242-x. Epub 2015 Jun 20.
Abstract | PDF | PMID: 26092662

Xue Z, You D, Candemir S, Jaeger S, Antani SK, Long LR, Thoma GR. Chest X-ray Image View Classification The 28th IEEE International Symposium on Computer-Based Medical Systems
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Antani SK. Automated Detection of Lung Diseases in Chest X-Rays April 2015 Technical Report to the LHNCBC Board of Scientific Counselors
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Candemir S, Antani SK, Jaeger SR, Thoma GR. Lung boundary detection in pediatric chest x-rays. Proc. SPIE. 9418, Medical Imaging 2015: PACS and Imaging Informatics: Next Generation and Innovations, 94180Q. (March 17, 2015) doi: 10.1117/12.2081060.
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KC S, Candemir S, Jaeger S, Folio L, Karargyris A, Antani SK, Thoma GR. Automatically detecting rotation in chest radiographs using principal rib-orientation measure for quality control. Int. J. Patt. Recogn. Artif. Intell, Vol 29 No. 2. DOI: 10.1142/S021800141.5570013
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KC S, Candemir S, Jaeger S, Folio L, Karargyris A, Antani SK, Thoma GR. Rotation detection in chest radiographs based on generalized line histogram of rib-orientations. IEEE 27th International Symposium on Computer-Based Medical Systems, New York, NY, USA, May 27-29, 2014: page 138-142.
Abstract | PDF | URL: http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6881864

Jaeger S, Karargyris A, Candemir S, Siegelman J, Folio L, Antani S, Thoma G. Automatic screening for tuberculosis in chest radiographs: a survey. Quant Imaging Med Surg. 2013 Apr;3(2):89-99. doi: 10.3978/j.issn.2223-4292.2013.04.03.
Abstract | PDF | PMID: 23630656 | PMCID: PMC3636475

Candemir S, Jaeger S, Palaniappan K, Musco J, Singh RK, Xue Z, Karargyris A, Antani SK, Thoma GR, McDonald CJ. Lung segmentation in chest radiographs using anatomical atlases with nonrigid registration. IEEE Trans Med Imaging. 2014 Feb;33(2):577-90. doi: 10.1109/TMI.2013.2290491. Epub 2013 Nov 13.
Abstract | PDF | PMID: 24239990

Jaeger S, Karargyris A, Candemir S, Folio L, Siegelman J, Callaghan FM, Xue Z, Palaniappan K, Singh RK, Antani SK, Thoma GR, Wang Y, Lu P, McDonald CJ. Automatic tuberculosis screening using chest radiographs. IEEE Trans Med Imaging. 2014 Feb;33(2):233-45. doi: 10.1109/TMI.2013.2284099. Epub 2013 Oct 1.
Abstract | PDF | PMID: 24108713

Karargyris A, Folio L, Siegelman J, Callaghan FM, Candemir S, Xue Z, Lu P-X, Wang Y, Antani SK, Thoma GR, Jaeger S. Comparing the Performance of Man and Machine for TB Screening in Chest Radiographs [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.
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Xue Z, Jaeger S, Karargyris A, Candemir S, Antani SK, Long LR, Thoma GR, McDonald CJ. A System for Automated Screening for Tuberculosis using Digital Chest X-rays for Resources-Constrained Regions [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.
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Karargyris A, Candemir S, Jaeger S, Xue Z, Antani SK, Thoma GR. A Combined Approach for Lung Boundary Segmentation of Chest X-Ray Images [Poster]. NIH Intramural Research Festival, Bethesda MD, November 6-8, 2013.
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Jaeger S, Karargyris A, Antani SK, Thoma GR. Detecting tuberculosis in radiographs using combined lung masks. 34th Int. Conf. of the IEEE Engineering in Medicine & Biology Society (EMBC). San Diego, CA. August 2012:4978-4981. doi: 10.1109/EMBC.2012.6347110.
Abstract | PDF | URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6347110&isnumber=6345844

Jaeger S, Karargyris A, Antani SK, Thoma GR. Automatic Screening For Lung Diseases In Chest Radiographs: a Global Health Initiative [Poster].. NIH Research Festival. October 2012.
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Candemir S, Jaeger S, Palaniappan K, Antani SK, Thoma GR. Graph Cut Based Automatic Lung Boundary Detection in Chest Radiographs. 1st Annual IEEE Healthcare Innovation Conference of the IEEE EMBS Houston, Texas USA, 7 – 9 November, 2012.
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Kamalakannan S, Gururajan A, Sari-Sarraf H, Long LR, Antani SK. Double-edge detection of radiographic lumbar vertebrae images using pressurized open DGVF snakes. IEEE Trans Biomed Eng. 2010 Jun;57(6):1325-34. doi: 10.1109/TBME.2010.2040082. Epub 2010 Feb 17.
Abstract | PMID: 20172792

Karargyris A, Antani SK, Thoma GR. Segmenting anatomy in chest x-rays for tuberculosis screening. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7779-82. doi: 10.1109/IEMBS.2011.6091917.
Abstract | URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6091917&isnumber=6089866 | PMID: 22256142

Jaeger S, Antani S, Thoma GR. Tuberculosis Screening of Chest Radiographs. 2 June 2011, SPIE Newsroom. DOI: 10.1117/2.1201105.003732i.
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Xu X, Lee DJ, Antani SK, Long LR, Archiband JK. Using Relevance Feedback with Short-term Memory for Content-based Spine X-ray Image Retrieval. J Neurocomputing. June 2009;72(10-12):2259-69.
Abstract